নেত্রকোণা মেডিকেল কলেজ, নেত্রকোণা

01. Introducion to Pharmacology

02:Drug Compendia (Information sources) Pharmacopoeiea, Formulary, Treatment guidelines (BP, INN, BNF and BDNF)

03. Drug Administration Routes, drug delivery and formulations for local & systemic effects

04: Drug Absorption Transfer of drugs across cell membrane & specialized barriers, Factors influencing absorption

05: Bio-availability Studies to compare bio-equivalence & to monitor therapy

06: Drug Distribution Vd, Plasma protein & tissue binding, redistribution

07: Drug Metabolism Where, why and how of bio- transformation, hepatic microsomal enzymes- induction & inhibition Genetic influence on Drug metabolism (Pharmacogenetics) Lectures/ Practical/ Tutorials/ Assignments 12 hrs Three item Examinations (Item 1,2,3) 100 Learning Objective Core Contents TeachingLearning Strategies Teaching Hours * Evaluations

08: Drug Elimination Routes, Renal Excretion & factors influencing renal excretion

09: Clinical Pharmacokinetics Vd, Cl, First & Zero order kinetics of Elimination, t½, Steady state concentration, loading dose & maintenance dose

10: Pharmaco-Dynamics: Specific and non specific mechanisms Receptors involved Second messenger system Enzyme mediated drug action

11: Quantitative aspects of drug action Dose-response relationships & curves Therapeutic Index and window-importance Information obtained from D-R curves Agonists – efficacy, potency, shift of curves Antagonists - efficacy, potency, shift of curves

12:Individual variations in drug responses

13. Drug Interaction at different levels

14: Drug safety and Pharmacovigilance Adverse drug reactions: Types, detecting & managing ADR ADR monitoring & reporting